Is there _______ wrong with you today?
A.nothingB.somethingC.a(chǎn)nythingD.everything
C

此題考查的是不定代詞+形容詞。anything一般用于否定句和疑問句,something用于肯定句以及希望得到對方肯定回答的疑問句中,如Would you like something to drink? 本題只是一般的疑問句,故選C。nothing表示什么也沒有,everything表示一切東西。
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