_______ what his parents think, he is leaving home for a new job in a big city.

A. Regardless of　　　　　　　　　　　　　　　　　　　　　　　 B. Instead of

C. In terms of　　　　　　　　　　　　　　　　　　　　　　　　 D. Lack of

解析：選A。句意：不管他父母怎么想的，他還是要離開家，去一所大城市找份新工作。regardless of不管，不顧；instead of代替；in terms of鑒于；lack of缺乏。

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