A serious illness, ______ its nature, is almost always painful.

A．whatever B．wherever C．whenever D．however

A

解析試題分析：考察讓步狀語(yǔ)從句，本句在nature后面省略了is。Whatever引導(dǎo)起這個(gè)讓步狀語(yǔ)從句，并在句中作為is 的表語(yǔ)。BCD三項(xiàng)都是副詞，通常不能在句中作表語(yǔ)。句意：無(wú)論是什么樣的性質(zhì)，一種嚴(yán)重的疾病總是會(huì)讓人痛苦。故A正確。
考點(diǎn)：考察讓步狀語(yǔ)從句

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