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He tried his best to solve the problem, 　　　　difficult it was.  
A．no matter whatB．whateverC．howeverD．how
C               
             
試題分析：考查狀語從句。句意：他努力去解決這個問題，無論它有多么的困難。后半句是讓步狀語從句，however相當于no matter how 后面跟形容詞或副詞,而whatever 等于no matter what后面跟名詞，故選C項。          
考點 : 考查狀語從句
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