He set off       his missing dog.
A．in search forB．search forC．search ofD．in search of
D
考查短語：search for 和 in search of為了尋找什么，題中已經(jīng)有了謂語動(dòng)詞，故用介詞短語作狀語，句意：他出發(fā)了為了尋找他失蹤的狗。故選D。
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